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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Dectin-1 levels in Obese and Overweight Women with Polycyctic Ovary Syndrome (PCOS)

Author: ZAINAB ALMUSAWI, NAMIR I. A. HADDAD, EKHLAS A.HUSSEIN
Abstract: Dectin-1 is a key innate immune receptor complicated in to various cellular responding and may have a role in inflammation.The object was to determine serum dectin-1 concentration and to assess its correlation with components of PCOS in obese and overweight women. This study included 52 women with PCOS (25 overweight and 27 obese subjects) and 28 healthy individuals without PCOS.Biochemical parameters and anthropometricindices for all subjects were measured. Serum dectin-1 was measured in these three groups and their correlations with other parameters were found.The data collected were analyzed by using test of ANOVA and Pearson correlation coefficient from software (SPSS). Results revealed that dectin-1 level is higher in obese group compared with overweight and control respectively (872.77±277.84 vs. 709.44±159.07 vs. 548.64±156.38). Dectin-1was correlated positively with WC (r = 0.462, P = 0.015), BMI(r = 0.460, P = 0.016)and WHtR (r = 0.461, P = 0.015) in obese subject. While in overweight group, serum dectin-1 levels were positively correlated with TC (r = 0.414, P = 0.040), LDL-C (r = 0.424, P = 0.035) and WHtR (r = 0.318, P = 0.036). From the obtained results, we concluded that dectin-1 levels may be associated with obesity and PCOS, so dectin-1 may act as biomarker for PCOS.
Keyword: Dectin-1, Obesity, Luteinizing hormone, PCOS, Follicle stimulating hormone.
DOI: https://doi.org/10.31838/ijpr/2020.12.02.0163
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