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Synthesis and Antimicrobial Activity of Some New Schiffbases Containing 2-Thienyl-3- Arylidine Substituted-4(3h) - Quinazolinone Derivatives.
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| Author:
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UPLOADED BY-ADMIN, P. PRAVEEN KUMAR, B. L. RANI, S. SRIDHAR
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| Abstract:
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Synthesis of 2-thienyl -3-[(substituted bezilidine) acetohydrazide] quinazoline-4(3H) one (8a-m) have been obtained
from the starting materials anthranilic acid (1) and chloro oxy thiophen (2) to 2-(2-thienyl-carbonylamino)-benzoic acid (3),
further reaction with acetic anhydride, formamide, ethylacetoacetate and hydrazine hydrate gave corresponding 2-(2-
thienyl)-4H-3,1-benzoxazin-4-one (4), 2-thienyl-quinazolin-4(3H) one (5), ethyl (4-oxo-2-thienyl-quinazolin-3(4H)-yl) acetate
(6), 2-(4-oxo-2-thienyl-quinazolin-3(4H)-yl) aceto hydrazide (7), this on condensation with different substituted aromatic
aldehydes afforded thirteen title compounds (8a-m). The newly synthesized compounds have been supported by IR,
H1NMR, Mass and elemental analysis. These compounds were tested for antibacterial and antifungal activity against a variety
of test organisms B. subtilis (NCIH 2063), B. pumilis (NCIH 2327), E. coli (NCIH 2807), P. vulgaris (NCIH 2027) and A.
niger (MTCC 227), C. albicans (MTCC 227) at 100µg/mL concentration and compared with the standard drugs Ampicillin
and Fluconazole.
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| Keyword:
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antibacterial, antifungal, schiffbase and 2-thienyl-3-substituted-quinazoline-4(3H) one
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| DOI:
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