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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Synthesis and Antimicrobial Activity of Some New Schiffbases Containing 2-Thienyl-3- Arylidine Substituted-4(3h) - Quinazolinone Derivatives.

Author: UPLOADED BY-ADMIN, P. PRAVEEN KUMAR, B. L. RANI, S. SRIDHAR
Abstract: Synthesis of 2-thienyl -3-[(substituted bezilidine) acetohydrazide] quinazoline-4(3H) one (8a-m) have been obtained from the starting materials anthranilic acid (1) and chloro oxy thiophen (2) to 2-(2-thienyl-carbonylamino)-benzoic acid (3), further reaction with acetic anhydride, formamide, ethylacetoacetate and hydrazine hydrate gave corresponding 2-(2- thienyl)-4H-3,1-benzoxazin-4-one (4), 2-thienyl-quinazolin-4(3H) one (5), ethyl (4-oxo-2-thienyl-quinazolin-3(4H)-yl) acetate (6), 2-(4-oxo-2-thienyl-quinazolin-3(4H)-yl) aceto hydrazide (7), this on condensation with different substituted aromatic aldehydes afforded thirteen title compounds (8a-m). The newly synthesized compounds have been supported by IR, H1NMR, Mass and elemental analysis. These compounds were tested for antibacterial and antifungal activity against a variety of test organisms B. subtilis (NCIH 2063), B. pumilis (NCIH 2327), E. coli (NCIH 2807), P. vulgaris (NCIH 2027) and A. niger (MTCC 227), C. albicans (MTCC 227) at 100µg/mL concentration and compared with the standard drugs Ampicillin and Fluconazole.
Keyword: antibacterial, antifungal, schiffbase and 2-thienyl-3-substituted-quinazoline-4(3H) one
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