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The value of two onset determination of anti-H.pylori IgM antibody in patients with dyspepsia in Iraq
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| Author:
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ASAAD ALZAIDY, ALI ALZAIDY, ISRAA NADHIM ABDULSATTAR
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| Abstract:
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Because of the strong humoral immune response that accompanies H. pylori infection, serological detection of
anti-H. pylori antibodies, particularly IgG, have been considered as a reliable tool for diagnosing recent infection as
well as assessing chronic infectious state. Actually, little has been mentioned, about the value of assessing IgM
before and after a proper course of antibiotic therapy against H. pylori.in the current study we tried to evaluate
such role by measuring serum IgM before and after anti-H. pylori therapy in a group of Iraqi patients with
documented H. pylori infection.The current prospective study was carried out in Adiwaniyah province, a midEuphrates
region
of
Iraq
and
included
317
patients
with
dyspeptic
symptoms
with
high
clinical
suspicion
of
H.
pylori.
The
age
range
of
those
patients
was
from
19
to
67
years
and
the
study
included
200
male
and
117
female
patients.
Those
patients were treated with anti-H. pylori antibiotic regimen according to medical textbook guidelines and
before starting treatment a venous blood sample was sent to the laboratory in order to measure the level of antH.
pylori
IgM
antibody.
After
the
end
of
a
single
course
of
antibiotic
therapy,
every
patient
was
subjected
to
another
serological
test
of
the
IgM
level.
The
IgM
level
was
assessed
by
ELISA
according
to
the
instruction
of
the
providing
company.
The
study
included
317
patients,
200
men
and
117
women
with
a
mean
age
of
35.61
±10.13
years.
Most
of
the
patients
were
from
urban
areas.
The
majority
of
patients
were
employed
or
students;
however,
a
substantial
proportion
of them was unemployed or retired. Illiteracy accounted for a substantial proportion of the study
sample 25.6 %. The mean body mass index was 26.51 ±7.81 kg/m
. The mean
serum IgM level was 55.22 ±16.50 U/ml before treatment and has been reduced to 36.75 ±6.05 U/ml after
treatment; the reduction was highly significant (P< 0.001).It appears that the serological evaluation of serum IgM
before initiation of anti-H. pylori antibiotic course and after completing that course is a promising method to assess
treatment response; however, much research work is needed to get a clear consensus about such a role.
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| Keyword:
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anti-H. pylori; IgM antibody; dyspepsia
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.02.0176
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| Download:
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