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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Synthesis, characterization and biological study of the ligand5-[(2Z)-2-(2,3- dimethoxybenzylidene)hydrzinyl]-1,3,4-thiadiazole2-thiol with some of its transition metal complexes

Author: ZAINAB KAREEM, IBRAHIM. A. FLIFEL, AHMED H. MOHAMMED
Abstract: A new series of transition metal ions (Cr(III), Co(III), Cu (II) and Ni(II) complexes with the ligand 5-[(2Z)-2(2,3-dimethoxybenzylidene)hydrzinyl]-1,3,4-thiadiazole-2-thiol were synthesized .A ligand was synthesized by reaction hydrazine hydrate , carbon disulfide and potassium hydroxide in ethanol as solvent . the product 1,3,4-thiadiazole 2,5-dithiole reaction with hydrazine hydrate again to give {2-thiol-5-hydrazineyl-1,3,4thiadiazole}, the resultant was mixed with 2,3-dimethoxybenzylidehyde to produce the ligand. The newly synthesized compounds were characterized by Fourier transform infrared (FTIR) Spectroscopy, Nuclear Magnetic Resonance Spectroscopy (1H NMR), elemental analyses (C, H, N,S), Mass Spectra data. The program Hyperchem 7.51 have been used for theoretical calculation using PM3 method to study the electrostatic potential, electron density, , heat of complexation, . It has been shown through all the above diagnostic measures that ligand is formed with the (Cu ,Co and Ni ) ions tetrahedral complexes and with the Cr formed octahedral complex. The study of cytotoxicity effect for ligand showed a good effect anti breast cancer cell which called MCF-7.
Keyword: 1,3,4-Thiadiazolederivative,,cytotoxicity, hyperchem.
DOI: https://doi.org/10.31838/ijpr/2020.12.02.0154
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