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Synthesis, characterization and biological study of the ligand5-[(2Z)-2-(2,3- dimethoxybenzylidene)hydrzinyl]-1,3,4-thiadiazole2-thiol with some of its transition metal complexes
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| Author:
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ZAINAB KAREEM, IBRAHIM. A. FLIFEL, AHMED H. MOHAMMED
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| Abstract:
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A new series of transition metal ions (Cr(III), Co(III), Cu (II) and Ni(II) complexes with the ligand 5-[(2Z)-2(2,3-dimethoxybenzylidene)hydrzinyl]-1,3,4-thiadiazole-2-thiol
were synthesized .A ligand was synthesized by
reaction hydrazine hydrate , carbon disulfide and potassium hydroxide in ethanol as solvent . the product
1,3,4-thiadiazole 2,5-dithiole reaction with hydrazine hydrate again to give {2-thiol-5-hydrazineyl-1,3,4thiadiazole},
the resultant was mixed with 2,3-dimethoxybenzylidehyde to produce the ligand. The newly
synthesized compounds were characterized by Fourier transform infrared (FTIR) Spectroscopy, Nuclear
Magnetic Resonance Spectroscopy (1H NMR), elemental analyses (C, H, N,S), Mass Spectra data. The program
Hyperchem 7.51 have been used for theoretical calculation using PM3 method to study the electrostatic
potential, electron density, , heat of complexation, . It has been shown through all the above diagnostic
measures that ligand is formed with the (Cu ,Co and Ni ) ions tetrahedral complexes and with the Cr formed
octahedral complex. The study of cytotoxicity effect for ligand showed a good effect anti breast cancer cell
which called MCF-7.
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| Keyword:
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1,3,4-Thiadiazolederivative,,cytotoxicity, hyperchem.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.02.0154
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| Download:
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