IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Evaluation of Mucoadhassive Gel of Liposomal Tetracycline (MAG Lipo T) of Antibacterial Vaginitis

Author: IMAN AL-SHATI
Abstract: Introduction: The objective of this experiment was to assess the antibacterial effect and activity of Nano liposome entrapped tetracycline and compared with ordinary tetracycline against different vaginal isolate bacterial strains from ewes estrus cycle programmed synchronization by sponges impregnated by Medroxy progesterone acetate. Methods: Four groups of ewes induced estrous synchronization by vaginal sponges and examined their sequel vaginal infection by BV blue test obtained the recovery of vaginitis in MAG Lipo T (as mucoadhesive tablet) higher than other groups and evaluation of antibacterial activity for different tetracycline formula of Liposome and ordinary tetracycline was carried out using the dilution assay and determination of minimum inhibitory concentration (MIC) and Minimum bactericidal concentration (MBC) on types of bacterial strain isolated from vagina. Results: the prevalence of bacterial isolate showed Staphylococcus species 52.3±4.925 and Escherichia coli 43.5±3.781 higher incidence than other strains Klebsiella pneumonia, Micrococcus species, and others. The MAG Lipo T showed MIC lower than tetracycline against Staphylococcus spp.0.031±0.004 µg/ml and 2.74±0.035 µg/ml, Escherichia coli 1.632±0.005 µg/ml and 6.52±0.166 and Klebsiella pneumonia 0.012±0.007 µg/ml and 0.51±0.031 µg/ml, Micrococcus spp. 0.164±0.095 µg/ml and 2.29±0.072 µg/ml respectively, the MBC values MAG Lipo T was showed 0.258±0.061 µg/ml, 4.351±0.245 µg/ml, 0.738±0.129 µg/ml and 2.650±0.018 µg/ml against Staphylococcus spp., Escherichia coli, Klebsiella pneumonia. Micrococcus spp. respectively lesser than ordinary tetracycline 16.25±1.963 µg/ml, 33.71±2.041 µg/ml, 11.58±1.680 µg/ml and 14.34±2.815 µg/ml. in addition, the Bacterial Cell count frequency distribution (CFU) ml-1 showed lower values in MAG lipo T than other groups. Conclusion: The findings of this study indicate that Nano liposome entrapped of the mucoadhesive tablet has antibacterial more officious than ordinary tetracycline against the vaginal bacterial types. This activity supports their practical usage in the prevention or treatment of vaginal infection due to the application of sponges.
Keyword: Antibacterial, Tetracycline, Liposome, MIC, Vaginitis, Medroxyprogesterone acetate Sponge, Nano.
DOI: https://doi.org/10.31838/ijpr/2020.12.02.0148
Download: Request For Article
 












ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free