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Synthesis, Characterization and Evaluation of the Biological Activity of Azetidin -2-carbonyl Derivatives of Thymine Nitrogenous Base
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| Author:
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SALWA SATTAR, SOHEIR ATIA KHALAF, AHMED HACHIM SULTAN
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| Abstract:
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This study involves the first four steps of synthesis of compound [S1] from the interaction of 2-chloro acetyl
chloride with thymine nitrogen base using trithylthenamine Et3N and the reaction was conducted within a
temperature [5 – 00C]. The second step is to prepare the compound [S2] from the reaction of the compound
[S1] prepared in the first step with the aqueous hydrazine compound (95%) in absolute ethanol using a strong
base medium. The third step is to prepare the hydrozones [S3-S10] from the reaction of the compound [S2]
prepared in the second step with some benzaldehyde compensators in absolute ethanol using an acid medium.
The fourth step was the preparation of a quadruple episode of aziteidine derivatives [S16-S10] from the
reaction of the prepared hydrozones with 2-chloro acetyl chloridein dioxane. The synthesized compounds
were characterized by spectral methods and physical with such as, FTIR, 1H-NMR, 13C-NMR, Melting point,
TLC. Antibacterial activity for some synthesized compounds have been tested on four know isolates bacteria,
Escherichia coli, Klebsiella pneumonia, Staphylococcus aurous and Staphylococcus Epidermidis. Some
compounds showed a good inhibitory against the bacteria used.
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| Keyword:
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Azetidin -2-carbonyl, Thymine Nitrogen Base, Aziteidine Derivatives, Hydrozones.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.02.0146
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| Download:
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