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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Improved Bioavailability of Atenolol With Piperine in Rats

Author: UPLOADED BY-ADMIN, AMAR SINGH, SUBHASH CHAND
Abstract: Piperine was established as bioenhancer to increase bioavailability of a large number of drugs. So an attempt has been taken to study changes in bioavailability of Atenolol in presence of piperine in rats. Male New Zealand white rats (100-200 g body weight) used for bioavailability study. All rats were divided in three groups. First group was considered as control and received only vehicle (distilled water) orally. Remaining two groups were treated with Atenolol and combination of Atenolol and piperine respectively. About 2 ml of blood sample was collected at the different time intervals and analyzed spectrophotometrically by High Pressure Liquid Chromatography. Cmax value of 22,453 (pictogram) pg/ml ±233 was obtained with atenolol alone (100 mg/kg) and 37,860 pg/ml ±348 with combination of atenolol (100 mg/kg) and piperine (10 mg/kg). This represents an increase of 68.6% in peak plasma levels of Atenolol. Reduction in total clearance from 0.27 ml/h ±0.005 to 0.25 ml/h ±0.010, and a volume of distribution from 4.54 L ±.0.786 to 2.88 L ±0.305 resulted in a net increase of 41.8 % in Area Under Curve (1, 07,189 pg.ml/h ±1615 to 1, 52,011pg.ml/h ±2354). So we can conclude that bioavailability of atenolol was significantly enhance in presence of piperine.
Keyword: Bioavailability; Atenolol; Piperine
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0.12
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