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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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In Vitro Bioequivalence Study of Formulated Atenolol Tablet with Marketed Brands

Author: UPLOADED BY-ADMIN, ANURADHA PATEL, JIGNA ROHIT, PARIXIT PRAJAPATI, RIKISHA BOGHRA, ANIL G JADHAV
Abstract: The aim of the present study was to predict the bioequivalence of formulated Atenolol tablet with marketed brands using in vitro tests. The in vitro dissolution study was carried out on the formulated of Atenolol tablet and marketed brands using the paddle method in 0.1 N HCL. Other general quality assessment tests like hardness and disintegration time were also determined. All the tested parameters were passed the Indian Pharmacopoeia standards (hardness, disintegration time). To find significant differences in the dissolution profiles of the formulated tablet and marketed brands calculation of similarity factor was performed. The formulated tablet, and marketed brands STD1, STD2 however, released >90% of Atenolol within 45 min. The formulated tablet and marketed brand (innovator brand) have calculated for similarity factors by considering the innovator brand STD1 as 100.Based on the in vitro tests, formulated tablet was considered bioequivalent and interchangeable with the innovator brand (STD1).
Keyword: Atenolol Tablets, Bioequivalence, Pharmaceutical Tablet Evaluation Tests, In Vitro Dissolution
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