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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Synthesis and Antifungal Activity of 6-Bromo-2-[(4-(3-chlorophenyl) piperazine-1-yl) methyl]-3-[8-ydroxyquinolin -5-yl]-3(H)-quinazolin-4-one Ligand [HL13] and Its Metal Chelates.

Author: UPLOADED BY-ADMIN, R.T. VASHI, C. D. SHELAT, HIMANSHU PATEL
Abstract: The present investigation involved the synthesis of novel ligand HL13 and its chelate complexes with Cu(II), Ni(II), Co(II), Mn(II) and Zn(II). The characterization studies of chelates were conducted using various physicochemical methods such as elemental analysis, conductometric studies, magnetic susceptibility, FT-IR, NMR and electronic spectral data. The stoichiometry of the complex has been carried out and found to be 1: 2 (Metal: ligand). An octahedral geometry around Co(II), Ni(II) and Mn(II), distorted octahedral geometry around Cu(II) and tetra hedral geometry around Zn(II) have been proposed. The antifungal activity of ligand and its metal chelates was performed against various fungi.
Keyword: 8-Hydroxy quinoline ligand, Complexes, Electronic, NMR spectral studies, Antifungal activity
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0.12
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