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Protective Role of DPP-IV Inhibitors Against Isoproterenol Induced Myocardial Ischemia in rats
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| Author:
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RUTVI VAIDYA,, BHAVIN VYAS, KRISHNA K. PAREKH, DR. SHAILESH SHAH
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| Abstract:
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Dipeptidyl Peptidase-IV (DPP-IV, DPP-4) is an enzyme belonging to cell-surface peptidase group of cell-surface proteases
that is involved in the regulation of the biological activity of small bioactive peptides that serve in cell communication,
namely peptide hormones, neuropeptides, growth factors, or cytokines. DPP4 transmits signals across cell membranes
and interacts with other membrane proteins. Regulatory peptides, chemokines, neuropeptides and several other
molecules are substrate for DPP-IV. This precipitates its contribution in various pathophysiological condition and
disorders. Inhibition of DPP-IV enzyme, prevents cleavage or deactivation of its substrate endogenous molecules such as
GLP-1, SDF-1, anti-oxidant substances, growth factors and various chemokines. DPP-IV inhibition provides protective as
well as curative effect due to intact activity of endogenous substances. In the present study protective role of synthetic
DPP-IV (sitagliptin, linagliptin, alogliptin) was evaluated against isoproterenol hydrochloride induced myocardial ischemic
injury in rats by estimation of cardiac biomarkers (CK-MB and SDF-1a) and biochemical antioxidant parameters
(Superoxide Dismutase(SOD), Catalase, Lipid peroxide(LPO)) along with Macroscopic enzyme mapping and
histopathology analysis compared between control, model control and treatment groups. The results showed marked
decrease in level of CK-MB and LPO and increase in level of SDF-1a and other anti-oxidants. Macroscopic enzyme
mapping grossly indicated less infarct area in treatment group as compared to model control group. Histology showed
no significant pathogenesis in DPP-IV inhibitor treated group unlike model control group. The results describes
cardioprotective role of DPP-IV inhibitors by precipitating preventive effect against isoproterenol induced myocardial
ischemic injury
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| Keyword:
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DPP-IV inhibitor, cardioprotection, SDF-1a, myocardial ischemic injury
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| EOI:
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| DOI:
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