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Formulation and Evaluation of Nanoparticles Containing Atenolol
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| Author:
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UPLOADED BY-ADMIN, AMAR SINGH, AMAR DEEP
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| Abstract:
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Atenolol is an antihypertensive agent used in the treatment of hypertension having moderate half-life of 6-7 hours thus
it is a good candidate for the formulation of sustained release dosage forms. In the present work atenolol loaded chitosan
nanoparticles were prepared by ionic gelation of chitosan with tripolyphosphate anions. Nanoparticles of different core: coat
ratio were formulated and evaluated for drug content, loading efficiency, particles size, zeta potential, in vitro drug release
and stability studies. Scanning Electron Microscopy indicated that the nanoparticles were found to be in nanometer range
and showed ideal surface morphology. Differential scanning calorimetry analysis indicated that there were no chemical
interactions between drug and polymer. The in vitro release behavior from all the drug loaded batches were found to follow
zero order and provided sustained release over a period of 24 hr. No appreciable difference was observed in the extent of
degradation of product during 60 days in which nanoparticles were stored at various temperatures. The developed
formulation overcomes and could possibility be advantageous in terms of sustained release dosage forms of atenolol.
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| Keyword:
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Nanoparticles, Chitosan, Atenolol, Ionic Gelation Technique.
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| EOI:
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| DOI:
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