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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Formulation and Evaluation of Nanoparticles Containing Atenolol

Author: UPLOADED BY-ADMIN, AMAR SINGH, AMAR DEEP
Abstract: Atenolol is an antihypertensive agent used in the treatment of hypertension having moderate half-life of 6-7 hours thus it is a good candidate for the formulation of sustained release dosage forms. In the present work atenolol loaded chitosan nanoparticles were prepared by ionic gelation of chitosan with tripolyphosphate anions. Nanoparticles of different core: coat ratio were formulated and evaluated for drug content, loading efficiency, particles size, zeta potential, in vitro drug release and stability studies. Scanning Electron Microscopy indicated that the nanoparticles were found to be in nanometer range and showed ideal surface morphology. Differential scanning calorimetry analysis indicated that there were no chemical interactions between drug and polymer. The in vitro release behavior from all the drug loaded batches were found to follow zero order and provided sustained release over a period of 24 hr. No appreciable difference was observed in the extent of degradation of product during 60 days in which nanoparticles were stored at various temperatures. The developed formulation overcomes and could possibility be advantageous in terms of sustained release dosage forms of atenolol.
Keyword: Nanoparticles, Chitosan, Atenolol, Ionic Gelation Technique.
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