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Development and Evaluation of Mucoadhesive Microspheres of an Anti-Diabetic Drug with Natural Polymer
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| Author:
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UPLOADED BY-ADMIN, NISHANTH KUMAR N, RAMAKRISHNA RAPARLA, SANTHOSH KUMAR M
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| Abstract:
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Gliclazide is an oral hypoglycemic agent used in the treatment of non-insulin dependent diabetes mellitus. Among the
people who are suffering from long term disorders, the major had been categorized under the people who are suffering from
diabetes and a dosage form is needed for them that should provide continuous therapy and should have a high margin of
safety. Microencapsulation plays a great role in providing such a kind of dosage form. Gliclazide microspheres with a coat
consisting of alginate and xanthan gum were prepared by orifice-ionic gelation method and emulsification gelation
technique. The prepared gliclazide microspheres were evaluated for surface morphology and particle shape, Carr’s index,
microencapsulation efficiency, drug release characteristics, compatibility studies rheological studies. The microspheres were
found discrete, more spherical and free flowing with emulsion ionic gelation technique. The microsphere size was found in
the range 498±12-598±10µm. Sharp endothermic peaks were found from the microspheres formulated with polymers
indicating the compatibility between the drug and the polymer xanthan gum. The encapsulation efficiency was found around
57.50±0.59%-61.68±0.43% and percentage drug content is in the range of 19.96±0.48% - 30.09±0.65%. Drug release from
the microspheres was found slow, followed zero order release kinetics with non-fickian release mechanism stating release
depended on the coat: core ratio and the method employed in the preparation of microspheres. Among two techniques
emulsification gelation technique was found to be more suitable for slow and complete release over a long period. These
microspheres showed good mucoadhesive property in the in vitro wash of test.
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| Keyword:
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Gliclazide, xanthan gum, orifice ionic gelation technique, emulsification ionic gelation technique.
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| DOI:
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