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DESIGN AND EVALUATION OF ALMOND OIL BASED WATER-IN-OIL MUCOADHESIVE MICROEMULSION FOR NOSE TO BRAIN DELIVERY
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| Author:
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UPLOADED BY-ADMIN, YADAV S R, GHOLSE Y N, KAWTIKWAR P S, SAKARKAR D M
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| Abstract:
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The present study was aimed to develop less viscous water-in-oil microemulsion for nasal delivery. Almond oil, tween 80
and span 80 were selected as oil phase, surfactant and co-surfactant respectively. Phase behaviour of almond oil/tween 80/span
80 has been studied. Several compositions from single phase region were selected, visually observed for phase clarity & stability.
These compositions were further evaluated for pH, conductivity, refractive index and viscosity. A least viscous, low
surfactant containing composition (water/almond oil/Smix as 10/45/45) (Smix is the mixture of Surfactant & Co-surfactant
used in the formulation) was chosen as the drug delivery system from clear water-in-oil single phase zone of pseudo ternary
system. Globule size of selected composition was determined by Malvern Zetasizer V2.0. Selected composition was loaded
with drug and mucoadhesive agent; chitosan. Comparative diffusion study confirms increase in drug release from mucoadhesive
microemulsion. Acute toxicity study results examined confirms non-toxic nature of formulation.
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| Keyword:
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Almond Oil, Microemulsion, Sumatriptan Succinate, Nose to Brain.
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| EOI:
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| DOI:
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