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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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DESIGN AND EVALUATION OF ALMOND OIL BASED WATER-IN-OIL MUCOADHESIVE MICROEMULSION FOR NOSE TO BRAIN DELIVERY

Author: UPLOADED BY-ADMIN, YADAV S R, GHOLSE Y N, KAWTIKWAR P S, SAKARKAR D M
Abstract: The present study was aimed to develop less viscous water-in-oil microemulsion for nasal delivery. Almond oil, tween 80 and span 80 were selected as oil phase, surfactant and co-surfactant respectively. Phase behaviour of almond oil/tween 80/span 80 has been studied. Several compositions from single phase region were selected, visually observed for phase clarity & stability. These compositions were further evaluated for pH, conductivity, refractive index and viscosity. A least viscous, low surfactant containing composition (water/almond oil/Smix as 10/45/45) (Smix is the mixture of Surfactant & Co-surfactant used in the formulation) was chosen as the drug delivery system from clear water-in-oil single phase zone of pseudo ternary system. Globule size of selected composition was determined by Malvern Zetasizer V2.0. Selected composition was loaded with drug and mucoadhesive agent; chitosan. Comparative diffusion study confirms increase in drug release from mucoadhesive microemulsion. Acute toxicity study results examined confirms non-toxic nature of formulation.
Keyword: Almond Oil, Microemulsion, Sumatriptan Succinate, Nose to Brain.
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0.12
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