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Screening of Antidiabetic and Antioxidant Potential of Tectona Grandis Bark Ethanol Extract
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| Author:
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UPLOADED BY-ADMIN, RAJKUMAR S BAGALI, SUNIL S JALALPURE
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| Abstract:
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Herbal medicines provide rational means for the treatment of many diseases that are obstinate and incurable in other
systems of medicine but it is necessary to establish the scientific basis for the therapeutic actions of herbal plant medicines
with the purpose of discovering new bioactive compounds for diabetes mellitus. Tectona grandis bark ethenol extract was
studied for the OGTT study and acute and sub-acute effects on alloxan induced diabetic rats. Blood glucose levels, Serum
lipid profiles and histological study of pancreas were performed. This extract’s DPPH radical scavenging potential was also
studied. After administration of ethanol extract of bark of Tectona grandis, reduction of fasting blood glucose levels took
place from 60 min (OGTT), blood glucose lowering potential percentage was 16 % at 6 hr (Acute study) and after 15 days of
treatment it was 54 % (Sub acute study). This extract also showed better activity in quenching DPPH radical. Oxidative
stress has been suggested as a contributory factor in the pathogenesis of diabetes. Alloxan causes diabetes through its ability
to destroy the insulin producing ? cells of the pancreas. The Tectona grandis bark ethenol extract has potent in vitro antioxidant
potential and marked antihyperglycemic activity, which may be due to the presence of flavonoids and quinones.
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| Keyword:
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Tectona grandis; antidiabetic; antioxidant; alloxan induced diabetic rats; hyperglycemic.
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| DOI:
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