IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Process Optimization for Double-Cone Blender and Application of Statistics

Author: UPLOADED BY-ADMIN, SHARMA HITESH, MITTAL SWATI, JAIN DARSHANA
Abstract: Mixing is probably the most widely performed unit operation in pharmaceutical manufacturing, in fact, it is difficult to find a product where mixing is not involved in some stage of the process It is difficult to determine, what degree of mixing is required in particular circumstances and ways to assess the same. Blending operation could be affected by the physical properties of the materials to be mixed, blending time, rotation speed and percentage of blender capacity. Poor uniformity of the blend is obtained especially during the mixing of low dose drug with large amount of excipient. Chlorpheniramine maleate is example of one such drug. Optimization of the mixing procedure in a double cone blender for a potent drug like Chlorpheniramine maleate was carried out. For uniform mixing of the blend following parameters were optimized blending time, rotational speed and fill volume. Statistical techniques like Analysis of Variance also known as ANOVA was applied to designed experiments to determine variations within a batch, within equipment or even due to operators. It proved to be a valuable tool in maintaining product and process uniformity by comparing two or more groups. This method can be employed in pharmaceutical industry for optimization of equipments for higher production output and uniform mixing of low dose drug.
Keyword: Double cone blender, Chlorpheniramine maleate, Optimization, ANOVA.
Download: Request For Article
 












ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free