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Effect of Polymer and Cross linking Agent Ratio on Drug Release Kinetic of Nifedipine Microspheres
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| Author:
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UPLOADED BY-ADMIN, GHOLSE Y N, YADAV S R
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| Abstract:
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Polymer and cross linking agent affects drug release of microsphere. Nifedipine microspheres were prepared using Ionotropic
gelation technique, varying polymer and crosslinking agent concentration and keeping concentration of Nifedipine
and sodium alginate, temperature and rpm constant. Various ratios of drug: polymer (Hydroxy propyl methylcellulose,
Eethylcellulose, Eudragit) (1:1, 1:2, 1:3 w/w), and cross linking agent (4%, 5%, 6% w/v) were studied. Aim of study is to
examine effects of this parameter on the particle size, percentage yield, entrapment efficiency and in-vitro release of Nifedipine
microspheres. Eethylcellulose, Hydroxy propyl methylcellulose and Eudragit microsphere show Percent entrapment in
range of 78.43-88.92%, 81.44-91.96%, 87.15-94.67% and drug release 76.36-92%, 75.08-94.59%, 84.15-95.89% respectively.
EU-6 batch were found to be optimizing in terms of percent yield (91.89%), percent entrapment (93.04%) and in-vitro
release (95.89%). Optimized formulations were subjected to scanning electron microscopy, FTIR and accelerated stability
study. The smooth surface of microspheres as seen by SEM due to complete homogeneity of drug and polymers. FTIR study
shows there was no incompatibility seen in between drug and polymer used. Accelerated stability study was carried out at 40
± 20C/75 ± 5 % RH condition for a month and found to retain their stability with respect to drug entrapment and drug release.
Thus, the variation in polymer/cross linking agent ratios have an influence on the physical characteristics of the microspheres
and increase in polymer and crosslinking agent concentration causes a decrease drug release by increasing the crosslink
density thereby creating barrier for drug diffusion.
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| Keyword:
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Crosslinking Agent, Microspheres, Nifedipine, Ionotropic Gelation.
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| DOI:
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