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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Effect of Polymer and Cross linking Agent Ratio on Drug Release Kinetic of Nifedipine Microspheres

Author: UPLOADED BY-ADMIN, GHOLSE Y N, YADAV S R
Abstract: Polymer and cross linking agent affects drug release of microsphere. Nifedipine microspheres were prepared using Ionotropic gelation technique, varying polymer and crosslinking agent concentration and keeping concentration of Nifedipine and sodium alginate, temperature and rpm constant. Various ratios of drug: polymer (Hydroxy propyl methylcellulose, Eethylcellulose, Eudragit) (1:1, 1:2, 1:3 w/w), and cross linking agent (4%, 5%, 6% w/v) were studied. Aim of study is to examine effects of this parameter on the particle size, percentage yield, entrapment efficiency and in-vitro release of Nifedipine microspheres. Eethylcellulose, Hydroxy propyl methylcellulose and Eudragit microsphere show Percent entrapment in range of 78.43-88.92%, 81.44-91.96%, 87.15-94.67% and drug release 76.36-92%, 75.08-94.59%, 84.15-95.89% respectively. EU-6 batch were found to be optimizing in terms of percent yield (91.89%), percent entrapment (93.04%) and in-vitro release (95.89%). Optimized formulations were subjected to scanning electron microscopy, FTIR and accelerated stability study. The smooth surface of microspheres as seen by SEM due to complete homogeneity of drug and polymers. FTIR study shows there was no incompatibility seen in between drug and polymer used. Accelerated stability study was carried out at 40 ± 20C/75 ± 5 % RH condition for a month and found to retain their stability with respect to drug entrapment and drug release. Thus, the variation in polymer/cross linking agent ratios have an influence on the physical characteristics of the microspheres and increase in polymer and crosslinking agent concentration causes a decrease drug release by increasing the crosslink density thereby creating barrier for drug diffusion.
Keyword: Crosslinking Agent, Microspheres, Nifedipine, Ionotropic Gelation.
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