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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Formulation and Evaluation of Controlled Release Glimepiride Osmotic Systems.

Author: UPLOADED BY-ADMIN, B. SAJEEV KUMAR, R. SARASWATHI, C. DILIP, VENKATES KUMAR, SAJAL KUMAR JHA
Abstract: The prime objective of this work is to develop controlled release formulation of glimepiride based on osmosis principle. The osmotic system comprises of glimepiride, Nacl as osmogent chitosan as release controlling polymer and evaluation was carried out by in-vitro release studies, burst strength test, IR analysis and stability studies. The concentration of pore forming agent, effect of osmotic pressure and effect of pH on drug release was also investigated. It was found that a non-zero order release was observed for 24 h period and the drug release varied with osmotic pressure which linearly relates with the concentration of pore forming agent. It was also noticed that pore forming agent have direct effect on drug release due to its water absorption capacity. Chitosan coated on the system was found to control the release rate due to its swelling nature in the dissolution medium. IR analysis proved the compatibility between drug and polymer. Stability studies indicated the stability of systems. It was concluded that by using osmotic principle and a suitable natural polymer like chitosan, controlled release drug delivery systems of other antidiabetic drugs can be developed.
Keyword: Controlled release; Glimepiride; Chitosan; Osmogent; Osmotic tablet; Stability.
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