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Zinc oxide nanoparticles and antibiotics mediated combinatorial approach to enhance antibacterial potential
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| Author:
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, , HARDEEP SINGH TULI, GURPREET KAUR, SHIVANI SOOD, DIKSHA SHARMA, PRABHJOT KAUR, PARDEEP KUMAR, AJINKYA G. NENE, SANDEEP PUNIA, ZAHOOR ABBAS, VINIT PRAKASH, MANOJ KUMAR
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| Abstract:
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Objectives: Bacterial diseases are increasing at an alarming rate. Therefore, the intention of this study was to examine the antibacterial action of Zinc oxide nanoparticles and their combined effect with different antibiotics including Erythromycin, Azithromycin, and Norfloxacin against various human pathogenic gram-positive (Staphylococcus) and gram-negative (Escherichia coli, Klebsiella, Shigella, Pseudomonas) bacterial strains. Methods: Synthesized ZnO nanoparticles were analyzed by using UV spectroscopy. The antibacterial activity of ZnO nanoparticles at different concentrations was determined by the agar well diffusion method.
Results: The results showed that ZnO nanoparticles possessed antibacterial effects and synergistic activities even on drug resistance Staphylococcus sp. We get the results of MIC in the range of 35-50 µg/ml. The synergistic action of antibacterial agents can reduce the need for high dosages, minimize side effects and reduces multidrug resistance. We have observed the highest synergistic effects against Escherichia coli and Staphylococcus sp.
Conclusion: These results signify that this nanoparticle potentiates the antimicrobial action of possible utilization of nano compounds in combination effect against drug-resistant bacterial strains.
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| Keyword:
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Zinc Oxide, Antimicrobial, Characterization, Metal Nanoparticle
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.03.007
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| Download:
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