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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Stress, Depression & Gut Microbiota: The Gut-Brain Axis Regulation

Author: ABHISEK PAL, RAKESH BARIK
Abstract: The multi physiological functions of gut-microbiota are well established now days. The efficacy of the gut–brain axis in regulating stress-related responses has long been appreciated. The microbiota has emerged as a key factor in the regulation of gut–brain axis, especially during conditions of stress induced homeostatic and metabolic challenges. Diet is one of the most important contributors of the microbiota-gut-brain axis. The path way of gut–brain communication are slowly being unravelled and include the vagal nerve, gut hormone signalling, the immune system, tryptophan metabolism and microbial metabolites such as short chain fatty acids. From the pre-clinical studies it was revealed that alterations of the early microbial composition by way of antibiotic exposure, lack of breastfeeding, birth by Caesarean section, infection, stress exposure, and other environmental influences - coupled with the influence of host genetics - can result in long-term modulation of stress-related physiology and behaviour. The role of gut microbiota has been implicated in different stress-related conditions including anxiety, depression and irritable bowel syndrome, although this is largely based on animal studies or correlative analysis in patient populations.
Keyword: gut–brain axis, stress-related disorders, depression
DOI: https://doi.org/10.31838/ijpr/2020.12.03.006
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