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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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The effect of Sida acuta on bacterial enzymes in azoxymethane-induced experimental colon cancer

Author: PERUMALSAMY MUNEESWARI, SRI RASHMY MADATHIL, KANNAPPAN POORNIMA
Abstract: Colon cancer constitutes as a serious global menace in incidence and mortality, in spite advances in diagnosis and treatment. It is due to changed life style and environmental factors. The effect of Sida acuta burm.f leaves, a herbal alternative, on bacterial enzymes as a prognostic marker in azoxymethane - induced experimental colon cancer is the aim of this study. A total of 21 male Wistar albino rats (120-150g) divided into seven groups of three rats in each group. Experimental colon carcinogenesis was induced by subcutaneous administration of azoxymethane 15mg/kg bw weekly once for two weeks. Following induction animals were subjected to treatment with different doses of ethanolic extract of Sida acuta. At the completion of the course of experimental duration, fecal matter and colon tissues was collected, homogenized and subjected for the assay of bacterial enzymes such as ß-glucosidase, glucuronidase, and Mucinase. The ethanolic extract of S.acuta showed significant protective effect with the manifestation of significant reduction in enzyme activity of fecal matter and colon tissues ß-glucosidase, glucuronidase, and Mucinase. Thus this study ascertains the hypothetical use of ethanolic extract of S. acuta burm.f leaves as a chemo protective agent for colon cancer development.
Keyword: Sida acuta, ß-glucuronidase, ß-glucosidase, mucinase, colon cancer, azoxymethane
DOI: https://doi.org/10.31838/ijpr/2020.12.03.004
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