IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Antidiabetic activity (In vitro alpha amylase inhibitory) of ethanol extract of Carissa carandas Linn. roots.

Author: SONIA SINGH
Abstract: Objective: The present research was designed to determine in vitro a-amylase inhibitory activity of ethanol extract of Carissa carandas Linn. root against porcine pancreatic amylase enzyme. Materials and Methods: Ethanolic root extract was prepared using soxhlet apparatus. The different concentrations of 20, 40, 60, 80, and 100 µg/mL of ethanolic root extract of C. carandas was dissolved in dimethyl sulfoxide, which was then used for in vitro alpha amylase inhibitory assay. The starch azure was used as substrate. The activity was measured at an absorbance of 595 nm using UV-spectrophotometer. The percentage of inhibition and IC50 value was evaluated and compared with the standard drug, Acarbose. Results: Ethanolic root extract attained potent effects in vitro a-amylase inhibitory activity of 71.16 ±0.01 % at 100 µg/mL with an IC50 value of 41.47 µg/mL, compared with acarbose as standard drug with IC50value of 84.42µg/mL. Conclusion: Ethanol extract of C. carandas Linn. root possessed effective in vitro a-amylase inhibitory property. For further aspects, this current study would be found helpful in the management of life style disorders, viz., diabetes.
Keyword: acarbose, absorbance, antidiabetic, % inhibition.
DOI: https://doi.org/10.31838/ijpr/2020.12.03.002
Download: Request For Article
 












ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free