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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Research of the Association of IL-17A RS (2275913) Gene Polymorphism with Allergic Rhinitis Associated with Food Co-sensitization

Author: NAZIFA DUSTBABAEVA, FATIMA IRSALIEVA, ZAYNITDIN KAMALOV, SHUKHRAT ZIYADULLAEV
Abstract: The Th17 cells are well known to participate in the pathogenesis of inflammatory allergic and autoimmune diseases, and are characterized by the predominant synthesis of cytokines IL-17A and IL-17F. The aim of this study was to evaluate the relationship between the polymorphism of IL-17A rs (2275913) and the presence of allergic rhinitis associated with food cosensitization (oral allergy syndrome) in the Uzbek population. 35 patients with allergic rhinitis associated with food cosensitization (oral allergy syndrome) were examined. As a control group, 103 healthy persons were examined. Genotyping of polymorphism IL17A rs2275913 using the method - polymerase chain reaction in real-time (Real-Time) "SNP-EXPRESS"-RV. The results obtained indicate a potential connection of SNP IL17A rs2275913 with allergic rhinitis associated with food cosensitization in the Uzbek population.
Keyword: allergic rhinitis, single-nucleotide polymorphism, genetic association study.
DOI: https://doi.org/10.31838/ijpr/2020.12.02.0116
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