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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Synthesis and Evaluation of Some Newer Pyrazolines as Possible Potential Antitumor Agents

Author: KALPANA DIVEKAR, SHIVAKUMAR SWAMY
Abstract: Worldwide data states that on an average 14.1 million people are diagnosed to be cancer patients and the number may reach 24 million by 2035 and major cause of death may be related to cancer. The research in the area of chemotherapy is of continuous interest for medicinal chemists as the chemotherapy suffers from major drawback of causing side effects. Moreover many molecules which are used in cancer do not exhibit target specificity. In view of this the search for new chemotherapeutic agents continues to be an active area of research. Among nitrogen containing heterocyclic compounds pyrazolines demonstrate various types of biological activities including cytotoxic activity. This work is aimed at synthesis of some pyrazole derivatives, their characterization and evaluation of their anticancer activity. Out of the ten compounds prepared it was found that two compounds have significant antitumor properties.
Keyword: Anticancer agents, Pyrazolines, Cytotoxicity
DOI: https://doi.org/10.31838/ijpr/2020.12.02.0091
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