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Therapeutic response to topical tacrolimus in refractory vernal keratoconjunctivitis: A case report
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| Author:
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MITRA AKBARI
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| Abstract:
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Purpose: Here we describe a case of severe and steroid-resistant limbal vernal keratoconjunctivitis with limbal papillary hypertrophy, stem cell deficiency and its pattern of treatment.
Methods: Case report
Results: The patient was a 21 years-old lady with a complaint of decreased vision, ocular surface burning and photophobia in both eyes since a few years ago. Her complains was aggravated since last year. Her past medical history was unremarkable. According to corneal impression cytology and incisional biopsy of the limbal hypertrophic lesions, the limbal vernal keratoconjunctivitis (VKC) with partially limbal stem cell deficiency had diagnosed. It was resistance to topical steroid therapy, therefore topical tacrolimus 0.05% improved her sign and symptoms and eventually the good visual acuity achieved with penetrating keratoplasty (PKP) and amniotic membrane transplantation (AMT) surgeries.
Conclusion: The limbal mass like hypertrophy may be the initial manifestation of VKC and should be considered in the differential diagnosis. In severe and refractory VKC, aqueous formulation of topical tacrolimus can be used and enhance graft survival in such complex cases.
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| Keyword:
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Vernal Keratoconjunctivitis, Limbal Stem Cell Deficiency, and Topical Tacrolimus.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.04.0328
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| Download:
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