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Application of Betahistine and investigating its effect on Targeting on Vascular Wall Aging
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| Author:
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SOLGALOVA A.S., SOLDATOV V.O., TAT’YANA G. POKROVSKAYA, OLESYA A. PUCHENKOVA O.A, SOF’YA YA. ZAPESOTSKAYA, ALEXANDR V. FEITELSON, LEV N. SERNOV, VLADIMIR YA. PROVOTOROV, VOLODYA G. PAHLEVANYAN
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| Abstract:
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Betahistine are routine drug in neurological practice, which is used to correct vertigo. The clinical efficacy of this drug can be caused not only by neuro-, but also by endotheliotropic action. In this review, the main information on the potential mechanisms for the implementation of vasoprotection, including metabolic, NO-ergic, anti-inflammatory and other components of the action are discussed. Betahistine as histamine receptors type 3 antagonist and histamine receptors type 1 and 2 agonist has a positive effect on cerebral and systemic hemodynamics, and due to anorexigenic action and the ability to stimulate lipolysis can ameliorate dyslipidemia as well as suppress the synthesis of pro-inflammatory cytokines and increase the expression of endothelial NO synthase.
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| Keyword:
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betahistine, endothelial dysfunction, atherosclerosis, histamine, vertigo
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.04.0324
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| Download:
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Request For Article
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