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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Cardiac Fibroblasts Mitochondrial Activity In The Presence Of Medicinal Preparations taking the Effect of Pharmacological

Author: SERGEY NADEZHDIN, EKATERINA V. ZUBAREVA, ELIZAVETA. A. BREDNIKOVA, EVGENIYA A. MOVCHAN, VERONIKA S. BELYAEVA, VLADIMIR YA. PROVOTOROV, ALEXANDR A. STEPCHENKO
Abstract: The investigations of cardiac fibroblasts mitochondria exercise using fluorescence probe MitoTracker Red CMXRos (Thermo Fisher Scientific, USA) and generation potential with MTT assay (Thermo Fisher Scientific, USA) were conducted under the control of antihypoxant (trimetazidine) and anticancer (doxorubicin, cytosol) therapeutic arrangements. It was revealed that medicinal preparations from the antitumor antibiotics group decreased mitochondria activity regardless of the cell state, unlike antitumor metabolites. Medicinal preparation trimetazidine increases cardiac fibroblasts' mitochondrial activity.
Keyword: cardiac fibroblasts, mitochondria, MTT assay, antitumor agent, antibiotic, antimetabolite, antihypoxant, cytotoxicity.
DOI: https://doi.org/10.31838/ijpr/2019.11.04.0323
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