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Cardiac Fibroblasts Mitochondrial Activity In The Presence Of Medicinal Preparations taking the Effect of Pharmacological
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| Author:
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SERGEY NADEZHDIN, EKATERINA V. ZUBAREVA, ELIZAVETA. A. BREDNIKOVA, EVGENIYA A. MOVCHAN, VERONIKA S. BELYAEVA, VLADIMIR YA. PROVOTOROV, ALEXANDR A. STEPCHENKO
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| Abstract:
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The investigations of cardiac fibroblasts mitochondria exercise using fluorescence probe MitoTracker Red CMXRos (Thermo Fisher Scientific, USA) and generation potential with MTT assay (Thermo Fisher Scientific, USA) were conducted under the control of antihypoxant (trimetazidine) and anticancer (doxorubicin, cytosol) therapeutic arrangements. It was revealed that medicinal preparations from the antitumor antibiotics group decreased mitochondria activity regardless of the cell state, unlike antitumor metabolites. Medicinal preparation trimetazidine increases cardiac fibroblasts' mitochondrial activity.
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| Keyword:
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cardiac fibroblasts, mitochondria, MTT assay, antitumor agent, antibiotic, antimetabolite, antihypoxant, cytotoxicity.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.04.0323
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| Download:
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Request For Article
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