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Investigating the Particular Phenolic Inhibitors of Arginase
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| Author:
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LILIYA KOROKINA, MIKHAIL V. POKROVSKII, MIKHAIL V. KOROKIN, OLGA N. POKOPEJKO, TATYANA G. POKROVSKAIA, PAVEL G. GALENKO-YAROSHEVSKY, ALEXANDR A. DOLZHIKOV, LYUDMILA V. REZNICHENKO, ELENA G. YAKOVLEVA
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| Abstract:
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Introduction: it has been previously shown that the hidden arginase two inhibitors have a definite endothelioprotective level. A procedure is intended for the targeted exploration for isolated arginase of inhibitors between unions of phenolic nature, introduced three compounds, separate arginase inhibitors. As a result of the study, the acute toxicity of the compounds obtained was studied.
Objectives of the study: to verify the decision of a phenolic compound, a particular arginase two inhibitors, which has the lowest acute toxicity among the compounds obtained.
Methods: The experiment was conducted on laboratory mice of both sexes. Substance administered intragastrically. Observation of the animals was carried out for 14 days.
Results: Summarizing the data obtained, it can be concluded that, after intragastric administration to mice, the investigated compounds of phenolic nature under laboratory ciphers KUD259, KUD972, KUD973 are slightly toxic.
Conclusion: As the leading candidate for the drug, it is advisable to consider the compound KUD972, which showed the highest LD50 values, and therefore has the lowest toxicity.
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acute toxicity, arginase inhibitors 2, compounds of phenolic nature.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.04.0318
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