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Investigating the Influence of Imidazole Receptor Agonists on the Ophthalmoscopy and Morphometric Parameters with the case of Simulated Retinal Ischemia-Reperfusion
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| Author:
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SERGEY LUGOVSKOY, ELENA A. LEVKOVA, VICTORIA V. BASHUK, ELIZAVETA YU. DUBOVTSOVA, IRINA N. DOLZHIKOVA, DARIA S. VAIN, OLEG S. GUDYREV, MIKHAIL V. KOROKIN
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| Abstract:
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Introduction: An urgent assignment of experimental and clinical pharmacology and ophthalmology is to investigate the medicine for correcting retinal ischemia.
Objective: Improving the pharmacological correction efficiency of the retinal ischemia-reperfusion with use the new substances related to imidazoline receptor ligands.
Materials and methods: The retinal ischemia-reperfusion model in rats was used, in which an increase in intraocular pressure is carried out by mechanical pressure to the front chamber of the eye for 30 min. The protective effects of the studied imidazoline receptor ligands: sodium salt of C7070, potassium salt of C7070 were evaluated based on the results of semi-quantitative assessment of the eye fundus condition during ophthalmoscopy and counting the specific number of neuronal nuclei in the inner nuclear layer.
Results and Discussion: The most pronounced protective effect is demonstrated by potassium salt of C7070 in a dose of 10 mg/kg, which is expressed in reaching the target values of the semi-quantitative assessment of the eye fundus condition and the specific number of neuronal nuclei in the inner nuclear layer. When the pathology is corrected with sodium salt of C7070 in a dose of 10 mg/kg, the semi-quantitative assessment of the eye fundus condition in the group decreased by 71.4% (p < 0.05), specific number of neuronal nuclei in the inner nuclear layer increased by 74,6% (p < 0.05) compared with the group without correction.
Conclusion: The obtained data give an experimental substantiation of the pharmacological correction possibility of retinal ischemia-reperfusion by imidazoline receptor ligands.
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Imidazoline Receptor Ligands, Sodium Salt of C7070, Potassium Salt of C7070, Retinal Ischemia-Reperfusion Model, Rats.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.04.0311
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