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Studying the Renoprotective Consequences of Non-Selective Imidazole Receptor Agonists
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| Author:
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ELENA LEVKOVA, ANTON L. PAZHINSKY, VICTORIA V. BASHUK, ELIZAVETA YU. DUBOVTSOVA, ALEXANDER A. DOLZHIKOV, EVGENIYA A. BESKHMELNITSYNA, DARIA S. VAIN, VLADIMIR V. GUREEV
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| Abstract:
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Introduction: Contemporary medication treatment of ophthalmic disorders connected with retinal ischemia is not always thriving enough that guarantees the importance of the search for new efficient drugs.
Objective: of the goal of this study is to promote the Improving the pharmacological correction efficiency of the retinal ischemic damage in the experiment using non-selective imidazoline receptor agonists.
Materials and methods: The retinal ischemia-reperfusion model in rats was used, in which an increase in intraocular pressure is carried out by mechanical force to the front chamber. The retinoprotective effects of the nonselective imidazoline receptor agonists: the sodium salt of C7070, the potassium salt of C7070 and C7070, treated with carbon dioxide, were estimated by the changes in the ratio of the amplitudes of the b- and a-waves of electroretinogramm – the b/a coefficient. Measuring the retinal microcirculation level was carried out using laser Doppler flowmetry.
Results and Discussion: The most pronounced renoprotective effect is demonstrated by potassium salt of C7070 in a dose of 10 mg/kg, which is expressed in reaching the target values of the b/a and the retinal microcirculation level. When the pathology is corrected with sodium salt of C7070 in a dose of 10 mg/kg, the microcirculation level increases by 70.4% (p < 0.05), b/an increased by 94% (p < 0.05) compared with the group without correction. With the correction of retinal ischemia by C7070, treated with CO2, in a dose of 10 mg/kg, the microcirculation level increased by 12% (p > 0.05), b/an increased by 84% (p < 0.05), compared with the group without correction.
Conclusion: The obtained data give an experimental substantiation of the pharmacological correction possibility of retinal ischemia by imidazoline receptor agonists.
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| Keyword:
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Imidazoline Receptor Ligands, C7070, Retinal Ischemia-Reperfusion Model, Rats
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.04.0309
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| Download:
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