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The Effects of Pharmacotherapies Given Within the First Month after a Traumatic or Aversive Event to Prevent Ptsd or Asd Compared: A Systematic Review and Meta-Analysis
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| Author:
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MANSOUREH JAMALI, MEHRI HOSSEINI
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| Abstract:
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Background and aim: Given the importance of treatment PTSD and ASD, The purpose of this systematic review and meta-analysis was to compare pharmacotherapies given within the first month after a traumatic or aversive event to prevent PTSD or ASD.
Method: MEDLINE, PubMed, Cochrane Library, Embase, ISI, google scholar were used as electronic databases to perform a systematic literature between 2010 to 2019. A commercially available software program (Endnote X9) was used for electronic title management. Searches were performed with keywords, “Post-traumatic stress disorder OR PTSD”, “Acute stress disorder OR ASD”,” pharmacotherapy”,” Hydrocortisone”, “Propranolol” “ß blockers” , “Morphine”, “Albuterol”, “Carvedilol”,” atenolol”,” metoprolol”, “Hydrocortisone”.
Result: A total of 425 potentially relevant titles and abstracts were found during the electronic and manual search. Finally, a total of eight publications fulfilled the inclusion criteria required for this systematic review. The pooled RR was 2.382 (95% CI 1.341–4.229), showing a 42% decrease in PTSD or ASD incidence in the pharmacotherapy relative to the control groups.
Conclusion: no persuading prove was found for the efficacy of all pharmacotherapies within the avoidance of PTSD or ASD
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| Keyword:
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Post-traumatic stress disorder, acute stress disorder, pharmacotherapies
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.04.0305
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| Download:
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Request For Article
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