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Use of sintering method in the design of floating drug delivery systems
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| Author:
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RAJESH AKKI, S. ANGALA PARAMESWARI, KOTHAPALLI BANNOTH CHANDRASEKHAR
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| Abstract:
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Amoxicillin is a broad spectrum antibiotic used for the treatment which includes helicobacter pylori. For better action of drug formulated the locally acting gastric floating drug delivery is preferred by applying sintering technique. Eudragit RS 100 is used to retard the drug release with HPMC to enhance floating lag time. All the formulation prepared by wet granulation method. Pre compression parameters were studied. Fourier transform infrared analysis was studied and reveals that there is no interaction between polymer and drug. . Results showed that floating time was decreased and total floating time was improved after thermal treatment. In vitro drug release was retarded upon exposure to different temperature and time. Sintered formulation of AE3 at 550C and the time of exposure is 2.5 h was selected based on drug retarding power.
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| Keyword:
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Eudragit RS 100, thermal treatment, floating, time of exposure
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.02.0084
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| Download:
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