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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Design and In Vivo Characterization of Novel Pulsatile Drug Delivery System of Biguanide Anti-Diabetic

Author: RAHUL PANDEY, W. SELVAMURTHY
Abstract: The aim of the current work was to design and develop pulsatile pellets of hydroxypropyl cellulose and eudragit in an admixture for a gastro-retentive drug delivery system. Pellets containing metformin hydrochloride (500 mg) were prepared by the pelletization technique using an extruder-spheronizer. Metformin hydrochloride spherical pellets were prepared, It was characterized by complete release of the drug in pulses after well-defined lag time of 6 h (± 0.20) (period of no drug release) for the treatment of diabetes mellitus. The novel drug delivery system consisted of HPC Type H as lag time modifier, and Eudragit L-100 and Eudragit S-100 in different concentration as pH dependent release modifier in gastrointestinal tract. The pellets of the selected batch were having spherical and smooth surface with maximum % yield of 78.98 %.The pellets were subjected to in vivo studies using HPLC and LC-MS for the optimized formulation. The AUC0 t, Tmax, Cmax, Cl, Vd was found to be 345.5, 53.6, 1471.3, 0.187, 89.9 respectively. The selected formulation batch-5 consisted of HPC Type in concentration (18 %); Eudragit L-100 (29 %) and Eudragit S-100 (19 %) w/w respectively.
Keyword: Metformin Hydrochloride, Pulsatile, Pellets, Hydroxy propyl cellulose, Eudragit L/ S-100
DOI: https://doi.org/10.31838/ijpr/2020.12.02.0058
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0.12
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