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FORMULATION, DEVELOPMENT AND EVALUATION OF CLARITHROMYCIN MICROEMULSION BASED GEL FOR TOPICAL DELIVERY
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| Author:
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SHAH DHIREN P, BHUMIKA CHHATRANI
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| Abstract:
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Clarithromycin, a macrolide antibiotic having strong antibacterial activity against gram positive bacteria. However, gastrointestinal use is accompanied with several side effect like nausea, vomiting, taste perversion, abdominal pain, diarrhea, headache, constipation, etc. Thus there is unmet need to develop an alternative delivery system that will be easy to administer and can avoid side effects associated with it. Present study was aimed to formulate, develop and evaluate microemulsion (ME) and microemulsion based gel (MBG) of Clarithromycin for topical delivery. Pseudo-ternary phase diagrams were utilized to prepare ME formulations. Effect of surfactant and co-surfactant mass ratio on the ME formation and permeation of ME were evaluated and formulation was optimized. Permeation studies were performed using excised rat skin was studied. Composition of optimized formulation was 1% (w/w) Clarithromycin, 6.32% (w/w) Capmul MCM EP, 58% (w/w) Smix (4:1, Acconon C30 and PEG 400). Optimized formulation showed globule size of 68.6 nm, polydispersity index of 0.341 and zeta potential of -34.6 mV. MBG was found safe in skin irritation study. Significant antibacterial activity of ME gel was observed in ditch plate method. In conclusion, results of present study suggest that ME could be a promising formulation for topical administration of Clarithromycin.
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| Keyword:
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Clarithromycin, Microemulsion based gel, Topical Drug delivery
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| EOI:
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| DOI:
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