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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Two Spectroscopic Methods for the Simultaneous Estimation of Indapamide and Nebivolol Hydrochloride in Combined Dosage Form.

Author: UPLOADED BY-ADMIN, PARESH U. PATEL, HETAL P. PATEL
Abstract: Two spectroscopic methods for simultaneous estimation of Indapamide and Nebivolol hydrochloride in combined tablet dosage form have been developed. The first method is simultaneous equations method which involves the formation of simultaneous equations at 241.6 nm (?-max of Indapamide) and 281.5 nm (?-max of Nebivolol hydrochloride). The linearity was observed in the concentration range of 2-12 ?g/ml and 10-50 ?g/ml respectively for Indapamide and Nebivolol hydrochloride. The second method is Q-analysis method (Q-absorbance ratio), which involves the formation of Q-absorbance equation at 274 nm (Iso-absorptive point) and 281.5 nm (?-max of Nebivolol hydrochloride). In this method the linearity was evaluated over the concentration range of 2-20?g/ml for both the drugs. The accuracy of the methods were assessed by recovery studies and was found to be 100.04 ?0.0607 and 99.85?0.94 for simultaneous equations method and 101.12?1.57and 98.26?1.18 for Q-absorbance ratio method for Indapamide and Nebivolol hydrochloride respectively. The proposed methods are simple, accurate, precise, rapid and cost effective. Therefore the proposed methods can be used for routine analysis of both drugs in bulk as well as in pharmaceutical formulations.
Keyword: Simultaneous equations methods and Q-analysis method, Iso-absorptive point, Indapamide and Nebivolol hydrochloride.
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