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Design & Development of Chronomodulated Pulsatile Tablets of Losartan
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| Author:
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SHAH DHIREN P, DESAI HIRAL
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| Abstract:
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Losartan potassium is first class of Angiotensin-II receptor antagonist and because of its vasodilatation action it is used as a form of chemotherapy for cardiovascular Disease. Conventional dosage form of Losartan potassium has a relatively poor pharmacokinetic profile. It necessitates 2-3 times daily dosing, which may reduce patient compliance. Because, this study is design and evaluate a chronomodulated pulsatile drug delivery system of Losartan potassium for the treatment of cardiovascular diseases like hypertension and congestive heart failure occurring in early hours of a day. The preformulation work was first carried out. An FTIR study was carried out for checking interaction between drug & polymers. The pulsatile tablets were prepared by using direct compression method. The formulations so prepared were evaluated for weight variation, thickness, hardness, disintegration time, dissolution time, friability, mucoadhesive strength, lag time. The optimized formulation was subjected to stability analysis. The FTIR studies showed no interaction between drug and polymer or other additives. It was concluded that formulation PCT8 containing 250mg of HPMC E10M pulsatile tablets was the best formulation among all other formulation as observed from the evaluation tests, stability analysis. It was concluded that pulsatile tablets can be considered suitable for clinical use in the treatment of Hypertensions.
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| Keyword:
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Losartan potassium, Chronomodulated delivery, Pulsatile Tablets.
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| EOI:
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| DOI:
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