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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Toxicity of Ag & ZnO nanoparticles against MCF – 7 cell lines whereas not toxic to human peripheral blood mononuclear cell lines

Author: KANTIPRIYA K, U S N MURTHY, SARVAMANGALA D, SATYANARAYANA R, NARSINGARAO B, RAJKIRAN A
Abstract: A leaf extract of Talinum triangulare was used for the synthesis of Ag & ZnO nanoparticles and the synthesized nanoparticles were evaluated for anticancerous activity against Breast cancer (MCF -7) cell lines and antibacterial activity against pathogens Staphylococcus aureus, Streptococcus and Pseudomonas aeruginosa. Different concentrations of Ag and ZnO NP’S were tested against human breast cancer cell lines. Among all the tested concentrations 2 µg/ml for Ag nanoparticles and 6 µg/ml for ZnO nanoparticles were showed significant cytotoxic activity against MCF -7 cell lines. They were also found to be less toxic and safe to mononuclear cell lines from human peripheral blood, which IC50 values of both Ag & ZnO nanoparticles represents as 2 µg/ml and 6 µg/ml. The antibacterial activity on tested organisms was found to be very potential and superior.
Keyword: Talinum triangulare, anticancerous activity, antibacterial activity, MCF – 7 cell lines, Ag & ZnO nanoparticles, mononuclear cells.
DOI: https://doi.org/10.31838/ijpr/2020.12.02.0059
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