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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Potency of Garcinia Gummi-Gutta (l.) Roxb. Fruit rind in ethane-1,2-diol induced calcium oxalate urolithiasis in male rats

Author: MADATHALA SREEKANTH, VEERASAMY HARIBASKAR, NUNNA BHEEMA LINGESWARA PRASAD
Abstract: The present study investigated the efficacy of an ethanolic extract of fruit rind of Garcinia gummi-gutta (L.) Roxb., (EEFRGGG) as a curative agent in ethane-1,2-diol induced calcium oxalate urolithiasis in rats. Animals of normal control received saline solution (2 mL/kg) and EEFRGGG control received extract (400 mg/kg) throughout the study. Remaining five groups received ethane-1,2-diol 0.75% v/v by adding in their ingesting water from day first to day twenty eight for the induction of renal calculi. From 15th day, standard control received Cystone in the dose of 750 mg/kg while test groups were treated with ethanolic extract in the doses of 100, 200 and 400 mg/kg respectively up to 28 days. Levels of urea, blood urea nitrogen (BUN), creatinine, uric acid in serum; urinary volume, urinary pH, and renal morphology were typical in normal and EEFRGGG control groups, but altered by ethane-1,2-diol; which were almost fully recovered by Cystone (750 mg/kg) and therapeutic intervention trials with EEFRGGG 100, 200 and 400 mg/kg respectively. Anti-urolithiatic effect of EEFRGGG 400 mg/kg was significantly (P<0.01) higher than EEFRGGG 100, 200 mg/kg and Cystone 750 mg/kg.
Keyword: Urolithiasis, Garcinia gummi-gutta (L.) Roxb., Cystone, Ethane-1,2-diol.
DOI: https://doi.org/10.31838/ijpr/2020.12.02.0057
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