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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Synthesis, Characterization, and Anticancer Activity Studies of New N-(5-phenyl-1,3,4- oxadizole-2-yl) propane hydrazide and its Transition Metal Complexes

Author: LAMYAA DAHHAM, IBRAHIM A. FLIFEL, ALYAA MAJID
Abstract: A new ligand of N-(5-phenyl-1,3,4- oxadizole-2-yl) propane hydrazide and its Cu(II), Co(II), and Ni(II) complexes were synthesized. These ligand and its complexes have been characterized by 1HNMR,mass,and Fourier transform infrared (FTIR)spectra, as well as magnetic susceptibility, elemental analysis[C, H, N] and conductance measurements. The program of Hyperchem 7.51 has been used up for theoretical accounts using PM method to study the electrostatic potential that provided good information about the complexity site.Depending to the results obtained we can suggested square planer geometrics for Co(II) and Ni(II) complex, while tetrahedral geometry for Cu(II) complex. In otherwise the ligand and its complexes screened for their anticancer activity. This research showed excellent results in comparison with Ciprofloxacin as standard drug
Keyword: ligand, complexes, characterization, HyperChem, electrostatic potential, anticancer
DOI: https://doi.org/10.31838/ijpr/2020.12.02.0076
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