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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Antihyperglycemic Effect of crude Extract of Spermacocehispidain alloxan Induced Diabetic Rat

Author: QUTAIBA QASIM
Abstract: One of the world’s widespread and well-known disorder is diabetes mellitus. It is being emerged as an epidemic as well as one of the most common health issue. And also it is really a big challenge to manage diabetes. Therefore, this leads to the need for research on the products that should be natural along with having the anti-diabetic properties. Aim: In this study, diabetic rat models were used for evaluating the effect of antihyperglycemicofcertainplants. Materials and methods: These rats were allowed to fast overnight and after that, according to 150 mg/kg body weight a fresh solution of alloxanis prepared and injected in rats to induce diabetes. Results:In the result, before and after supplementing the plant extracts on the diabetic rats, the lipid profile has been studied. Furthermore, the plant extract’s ameliorative effect is also studied. As compared to the normal group, in the diabetic group the GPx, GST, CAT, and SOD levels were decreased, however, these levels have risen up to nearby normal due to the plant extract supplementation. Conclusion: The male albino rat has been affected by a strong antidiabetic effect that includes the Spermacocehispida’saqueous leaf extract.
Keyword: Hyperglycemic, Oxidative stress,Plants, Diabetic, Alloxan.
DOI: https://doi.org/10.31838/ijpr/2020.12.02.0073
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0.12
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