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Formulation and evaluation of cream for treatment of scabies
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| Author:
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P KULKARNI, SANJAY A, D V GOWDA, JUTUR SURYATEJA, AKHILA AKKIHEBBAL RAVIKUMAR
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| Abstract:
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The purpose and prospective of the work exertion is to formulate and carryout evaluation study of medicated cream composed of gelling agent and emulsifier for the treatment of Scabies. An o/w cream for scabies loaded with Permethrine is prepared by dispersion method. Performed comparative diffusion studies by discriminating diffusion media. Carbomer homopolymer type B was used as a gelling agent. Glyceryl monostearate, polyoxyethylene cetyl ethers and lanoline alcohol were used in combination as emulsifiers. In this formulation mineral oil and fractionated coconut oil was used as oil phase. An FTIR and DSC study suggests that no chemical interactions present between drug and polymer. Solubility studies were carried at different compendial medium. Optimised cream was further evaluated for pH, Viscosity, particle size, spreadability, drug content, water content, formaldehyde content and comparative diffusion with reference to the Reference Listed Drug (RLD), using Ethanol: PBS (50:50) and Ethanol: PBS (80:20) as a diffusion medium. Stability studies were carried out on prepared formulation for homogeneity and drug content. Thereof the prepared, developed and formulated o/w cream to be effective for the treatment of Scabies.
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| Keyword:
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Cream, Carbomer, Lanoline, Coconut oil, Scabies.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.02.0072
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| Download:
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Request For Article
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