|
Anti-arthritic effect of Sulforaphane (SFN) in FCA-induced arthritic rats by suppressing pro-inflammatory cytokines and tissue regeneration
|
|
| Author:
|
SANGEETA MOHANTY, ABHISEK PAL, TRIPTI SHARMA, SHIKHA SINGH, V BADIREENATH KONKIMALLA, SUDAM CHANDRA SI
|
| Abstract:
|
Sulforaphane (SFN), is an innately occurring isothiocyanate, mostly observed in cruciferous vegetables like broccoli is well-studied for its anti-cancer activity and anti-inflammatory studies. However, its anti-inflammatory property in a rheumatoid arthritis (RA) condition is not reported to date. The present investigation is a first report on comprehensive evaluation of anti-arthritic activity of SFN in FCA-induced arthritic rats. Here, the levels of immuno modulatory cytokines (TNF-a, IL-6, INF-?, IL-10); oxidative stress biomarkers (GSH, SOD, Catalase) supported by hematology, histopathology and radiological studies were assessed.The modulation of inflammatory mediators also evidently supported by docking studies. Treatment with high dose of SFN (5mg/kg) significantly decreases the production of signaling molecules like TNF-a, IL-6, INF-? which subsequently enhances the production of anti-inflammatory cytokinesis IL-10 in FCA induced arthritic rats (p<0.01). Histopathological studies reviled a significant reduction in synovial inflammatory in-filtration with synovial lining hyperplasia in SFN treated animals. Taken together, these findings suggest that SFN has a beneficial effect on chronic inflammatory disorders.
|
| Keyword:
|
Sulforaphane, Rheumatoid arthritis, Cytokine, Freund’s Complete Adjuvant.
|
| EOI:
|
-
|
| DOI:
|
https://doi.org/10.31838/ijpr/2020.12.02.0052
|
| Download:
|
Request For Article
|
|
|