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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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New Turbidimetric Method for Determination of Ketotifen Fumarate in Pharmaceutical Drugs by using line-continuous flow injection manifold design of KTF-Ammonium molybdate (Am) system

Author: NAGAM TURKEY, AHMED J. SALEEM
Abstract: A new turbidimetric, simple, sensitive and fast method for determination of Ketotifen-fumarate via the on line -continuous flow injection manifold design of KTF-Ammonium molybdate (Am) system. The method based on the reaction between KTF with Am in aqueous medium to form a gray-white colour precipitate as an ion pair complex, using continuous flow injection system of a new homemade ISNAG-fluorimeter. Chemical and physical parameters were studied and optimized.The calibration graph was the linear dynamic in the range of (0.05-5.5 mmol.L-1) which was better representation, with correlation coefficient r=0.9999.The limit of detection (LOD) 20.420 ng/sample from the stepwise dilution for the minimum concentration in the linear dynamic ranged of the calibration graph with RSD% lower than 0.15 % for the 2.3,10 mmol.L-1 (n=8) concentration of Ketotifen Fumarate. The method was successfully applied for the determination of Ketotifen-fumarate (KTF) in three pharmaceuticals preparation of different companies. A comparison was made between the newly developed method analysis with the classical method (HANNA instrument for turbidity measurement) using the standard addition method via the use of individual and paired t-test and F-test. It was noticed that there was a significant difference between two methods at 95 % confidence level.
Keyword: Ketotifen - Fumarate, Turbidity, Continuous flow injection analysis
DOI: https://doi.org/10.31838/ijpr/2020.12.02.0046
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