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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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First Derivative Spectrophotometric Method for Simultaneous Estimation of Pantopra-zole and Cinitapride in Combined Dosage Form.

Author: UPLOADED BY-ADMIN, PARESH U. PATEL, SHIVANG K. PRABTANI
Abstract: A new, rapid, precise, accurate and sensitive first derivative spectrophotometric analytical method is proposed for the simultaneous estimation of Pantoprazole and Cinitapride in combined dosage form. The drugs obeyed the Beer’s law in the concentration range of 1-26 ug/ml. In the proposed method, absorbance was measured at 302 nm (Zero Crossing Point of Cinitapride) and 249 nm (Zero Crossing Point of Pantoprazole). Accuracy of the method was determined by recovery studies and was found to be 100.35 ? 0.18 and 99.61 ? 0.17 for Pantoprazole and Cinitapride respectively. The proposed method is simple, accurate, precise, rapid and cost effective. Therefore the proposed method can be used for routine analysis of both drugs in bulk as well as in pharmaceutical formulations.
Keyword: First derivative spectrophotometric method, Pantoprazole and Cinitapride
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0.12
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