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Design and Development of Tacrolimus Niosomal Gel for Treatment of Psoriasis
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| Author:
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VRUNAL V.MORE, PRAJAKTA K.KHULE, MANOJ M.NITALIKAR, RITU M.GILHOTRA
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| Abstract:
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The aim of the study was to investigate the feasibility of niosomes as a drug delivery system of tacrolimus for
treatment of psoriasis. Present study was carried out by preparing total nine formulations (NF1-NF9) of niosomes
of tacrolimus using appropriate ratio of surfactant and co-surfactant by thin film hydration method and prepared
niosomes formulation were evaluated for Vesicle diameter, Drug content, Drug entrapment efficiency, & in-vitro
drug release. Best batch thus selected was further formulated as niosomal gel F1-F10 using different gelling agents
that is HPMC, Sodium alginate, Carbapol, Xanthan gum, Guar gum Prepared gel was evaluated for various
physicochemical parameters like Clarity, Homogeneity, Spreadability, Extrudability, pH, Drug content, Viscosity &
in-vitro drug release. From these results it may be concluded that formulation F6 small vesicles size, high
percentage of entrapment with the desired sustained release of tacrolimus
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| Keyword:
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Physico-chemical parameters, Psoriasis, Xanthan Gum.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.01.165
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| Download:
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