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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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The effects of saffron on psychiatric disorders: A review

Author: RAZIE EGHTESADI, SOMAYE SAFAVI, MORAD RASOULI-AZAD, AMIR GHADERI
Abstract: Psychiatric disorders are serious health problems and major contributors to the global burden of disease. Asian and European healthcare models, integration of psychotropic herbal medicines into conventional medical practice appears to still be some way off. Evidence reported show that saffron may be involved in neurodevelopment adult brain. The potential neuroprotective effect of saffron is linked to modulate several neurological pathways, including enhancing the immune response, decreased ROS, the activation of peroxisome proliferator-activated receptor alpha, and the regulation of nuclear factor kappa B activation, there are evidence studies that crocin intake might have anti-apoptotic, anti-inflammatory, and antioxidant effects. Saffron is being explored as an adjunctive therapy for drug addiction and addiction management. We here review the role of saffron in the psychiatric disorders, such as mental disorders (depression, anxiety, sleep, and sexual), cognitive functions, schizophrenia, addiction, obsessive–compulsive disorder, attention-deficit/hyperactivity disorder, and Eating disorder. Adequate administrate of saffron seems to be crucial in terms of psychiatric disorder management. Saffron is safe and well tolerated when administered orally but has documented risks with intravenous administration. An evidence study supports its use as an adjunctive therapy clinically for psychiatric disorders, administered concomitantly with existing medications. The aim of this review is to assess the current knowledge related to the role of saffron administration on psychiatric disorders. Future research directions will be suggested.
Keyword: saffron, psychiatric disorders
DOI: https://doi.org/10.31838/ijpr/2020.12.02.0043
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