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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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The influence of the Gln223Arg polymorphism of leptin receptor gene on the anthropometric and hormonal parameters of obese reproductive age women.

Author: TAKHMINA RASULEVA, DILOROM NAJMUTDINOVA, NEGINA ADKHAMOVA
Abstract: The Gln223Arg polymorphism (rs1137101) of leptin receptor gene has been studied in numerous studies and is related to various metabolic disorders. The impact of this polymorphism on overweight expansion in women of fertile age remains an important issue. Our aim in this study was to study the frequency of genotypes Gln223Arg and its alleles in a group of Uzbek women divided by body mass index to correlate LEPR genotypes with variations in anthropometric, lipid and hormonal parameters. Materials and methods: The study included 149 obese women and 33 healthy women of reproductive age. All women underwent clinical and laboratory examination including anamnesis collection, anthropometric parameters (height, weight, waist circumference, hip circumference), on an empty stomach determined glucose, lipids, insulin, leptin, also body mass index, ratio of waist to hip volume and HOMA index were calculated. Results: the study showed the presence of all three genotypes of Gln223Arg in Uzbek women, but the frequencies were significantly different in comparison with the reports of other researchers. No reliable differences in genotypes and allele frequencies between normal weight and obese women were found. A higher body mass index, waist and hip circumference, leptin, insulin, blood glucose on an empty stomach and the HOMA-IR were found in carriers of the GG genotype. Conclusions: According to the data obtained, it can be concluded that some structural changes caused by a mutation of a given genotype affect signaling pathways through an unknown mechanism, which may contribute to the manifestation of anomalies in persons carrying the allele G rs1137101.
Keyword: overweight, obesity, fertile age women, genetics of obesity, leptin receptor.
DOI: https://doi.org/10.31838/ijpr/2020.12.02.0027
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