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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Assessment of the effects of the combined cotrimoxazole and aqueous extract of Punic granatum against Salmonella Typhi in vitro model

Author: SAHAR MAJEED, HUSSEIN ABDALKADHIM, HIDHAB JAWAD
Abstract: Typhoid fever is a disease caused by Salmonella Typhi and commonly treated by an antimicrobial agent such as cotrimoxazole. Natural product and some plant extract usage have risen as an adjunctive therapy to treat many diseases. Aim of the study • To increase anti-salmonella efficacy of cotrimoxazole by combing with aqueous seed extract of Punicgranatum. • To prevent salmonella Typhi resistant by combination of antibiotic which is proved to treat this microorganism with aqueous extract of Punicagranatum? Material and method S.Typhi had been isolated and spp. Identified to be prepared as a module of anti-salmonella, isolation microorganisms cultivated for MIC determination of cotrimoxazole and aqueous Punic extract each one alone and their combination index. Result The minimum inhibitory concentration assay of the test combination between cotrimoxazole and the aqueous extract of Punicgranatum in micro/ml showed a noticeable increase in potency by combining the two test agents from 125 microgram /ml, 250 microgram/ml to 62.5 microgram/ml in cotrimoxazole, aqueous extract of Punicgranatum and the combination respectively P-value <0.05. Conclusion There was a strong synergism between cotrimoxazole and p. granatum aqueous extract against Salmonella Typhi in culture.
Keyword: salmonella Typhi, cotrimoxazole, Punic granatum
DOI: https://doi.org/10.31838/ijpr/2020.12.02.0023
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