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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Effect of tetracycline and verapamil on reproductive hormones and liver enzymes of female albino rats

Author: WATHEQ , ORASS SAAD KHAYOON, SALAM H. FLAYYIH, KHALID G, AL-FARTOSI
Abstract: The present study was performed to comparative the impact of tetracycline and verapamil on the liver and reproductive system in female rats. Twenty four of female rats were utilized in this study, were divided into four groups, the first group (control group) was treated orally with (1 ml/animal) of distill water. The second group was treated orally with (1 ml/animal) of (3.57 mg/kg) of tetracycline. The third group was treated orally with (1 ml/animal) of (0.57 mg/kg) of verapamil. The fourth group was treated orally by (0.5 ml/animal) of (3.57 mg/kg) of tetracycline and (0.5 ml/animal) of (0.57 mg/kg) of verapamil. The period of treatment was 15 days as one dose daily. The result shows marked decreased in FSH, LH, and estrogen with marked and increase in liver enzymes AST, ALT, ALP after administration of tetracycline, while administration of verapamil result in marked decreased in FSH, LH, estrogen and has no effect in AST, ALT, ALP. The present study show the bad effects of the two drugs on the fertility and sex hormones in group 4 compared with control group and group 2,3. Also the result showed benefit impact of verapamil against liver damage caused by tetracycline in group 4 compared with group 2,3.
Keyword: Tetracycline, Verapamil, Rats.
DOI: https://doi.org/10.31838/ijpr/2020.12.02.0014
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0.12
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