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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Formulation, in-vitro and ex-vivo Evaluation of Transdermal Therapeutic System for Diclofenac Diethylamine by Using Box-Behnken Statistical Design

Author: SRILATHA MALVEY, J VENKATESHWAR RAO, A KOTTAIMUTHU
Abstract: The purpose of present study was to develop transdermal patch of Diclofenac Diethylamine (DDEA) for its prolonged therapeutic usage. Transdermal patch was optimized by using Box-Behnken design by taking three factors, at three levels. Design expert software is used to find the effect of their independent variables (X1= Polymer concentration (mg), X2= Polyethylene glycol 400 % v/w (PEG-400), X3= Permeation Enhancer (DMSO) % v/w on dependent variables (Y1= in vitro Q24 cumulative amount of drug permeated, mg (CADP In-vitro), Y2=Flux, µg/cm2/hr. Y3= Tensile strength, (MPa). Mathematical equation was generated for Y1Y2Y3 Contour Plots; 3D plots are generated to find the effect of independent variables on dependent variables. Optimized formulation was selected by overlay plots of Response surface methodology. The optimized formulation showed a flux of 376.19 µg/cm2/hr, which could meet target flux.
Keyword: Matrix type TDDS; Diclofenac diethylamine; Optimization; RSM; Box-Behnken; Flux
DOI: https://doi.org/10.31838/ijpr/2020.12.02.0013
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