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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Aneurysmal Subarachnoid Hemorrhage: An Overview

Author: AADHARSA SUGUNAN, ANANDU H, ANILA K.N, SREEHARI N.R
Abstract: SAH is a medical condition characterized by bleeding into the subarachnoid space. It can be congenital or acquired form of disease, the major causes being ruptured intracranial aneurysm (85%), AVM or head injury and other inherited conditions such as autosomal-dominant polycystic kidney disease, Ehlers Danlos Type 4 and familial intracerebral aneurysms. Most of the aneurysms take place in the Circle of Willis adjacent to bifurcations. Subarachnoid hemorrhage is usually assumed to occur in people who complaint about a severe and sudden headache from the maximum intensity from the outset. This type headache is fundamental and is often referred as ‘thunder clap headache’ and descried as ‘the worst headache in my life’. The first line investigation method for detecting hemorrhage in subarachnoid space is non-contrast computer tomography (CT) with high sensitivity of about 95-100% on the first day. Treatment strategies for SAH vary, depending on the factor responsible for bleeding and extent of damage to the brain. SAH due to ruptured aneurysm is usually treated surgically via clipping or endovascular coiling. Nimodipine, a dihydropyridine calcium channel blocker(CCB) and is the only FDA specified medication for the reduction of neurologic deficits occurring due to cerebral vasospasm post SAH.
Keyword: Subarachnoid Hemorrhage, Computer Tomography, Aneurysm coiling or clipping, complications and Nimodipine.
DOI: https://doi.org/10.31838/ijpr/2020.12.02.0011
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